The Microfluidics and Laboratory Automation Research Group (Kinahan Lab) is an academic research group based in the School of Mechanical and Manufacturing Engineering in Dublin City University. The focus of group activities is on using microfluidics and automation to address challenges in areas as diverse as human health, animal health, agriculture, and the environment. The group if focussed on miniaturising and automating standard laboratory tests and deploying them in the field.
About the PI
David Kinahan BEng PhD
Since October 2018, Dr David Kinahan is an Assistant Professor in the School of Mechanical and Manufacturing Engineering. David completed a BEng in Aeronautical Engineering (2003) and a PhD (2008) at University of Limerick (UL). His PhD focused on high-throughput droplet microfluidics for DNA analysis. In late 2007 David joined Stokes Bio Ltd, a spin-out from UL, as a Senior Engineer, and was later promoted to Engineering Manager leading a team of 10 engineers. David did post-doctoral research from 2012 to 2018 in DCU before moving to his current position. David’s research applies microfluidics to a wide range of areas including human health (HIV diagnostics, CTC detection, CVD diagnostics, liver disease, early detection of bacterial meningitis) and point-of-use testing (plant pathogen detection, environmental monitoring etc).
Meet the Team
Mubashar (Moby) Muhammad Saeed BEng MEng
PhD Student (2022-2026)
Moby joined DCU to work in Kinahan Lab as a result of securing the prestigious Government of Ireland - International Education Scholarship. Moby then secured funding through the SFI ML-Labs Centre for Research Training to complete a PhD in Nanoparticle Synthesis using microfluidics with an emphasis on using Machine Learning techniques for process control. Moby’s PhD is co-supervised by Dr Eadaoin Carthy and Prof Nicholas Dunne.
Moby has a Bachelors in Mechanical Engineering from the University of Engineering and Technology Lahore, Paskistan (2016-2018) and a Masters in Mechanical Engineering from Nanjing University of Science and Technology, China (2018-2021). Moby is highly active in Student’s Union politics. He was previously the DCU-SU Postgraduate Officer and was recently elected the USI Vice President for Postgraduate Affairs.
Our Academic Collaborators
Prof James Landers (University of Virginia, USA)
Dr Mehdi Aeinevand (Tec De Monterrey, Mexico)
Dr Dario Mager and Prof Jan Korvink (Karlsruhe Institute of Technology, Germany)
Dr Tanya Dreo (National Institute of Biology, Slovenia)
Dr Celina Miyazaki and Dr Marystela Ferreira (Federal University of Sao Carlos, Brazil)
Dr Kevin Nolan (University College Dublin, Ireland)
Dr Kinga Zor and Prof Anja Boisen (DTU, Denmark)
Dr Des Brennan and Dr Paul Galvin (Tyndall National Institute, Ireland)
Publications
43. Julius, Lourdes AN, Muhammad Mubashar Saeed, Tim Kuijpers, Sergei Sandu, Grace Henihan, Tanja Dreo, Cor D. Schoen, Rohit Mishra, Nichoas J Dunne, Eadaoin Carthy, Jens Ducrée, and David J Kinahan. "Low–High–Low Rotationally Pulse-Actuated Serial Dissolvable Film Valves Applied to Solid Phase Extraction and LAMP Isothermal Amplification for Plant Pathogen Detection on a Lab-on-a-Disc." ACS omega (2024).
2024
42. Julius, Lourdes AN, Sarai M. Torres Delgado, Rohit Mishra, Nigel Kent, Eadaoin Carthy, Jan G. Korvink, Dario Mager, Jens Ducrée, and David J. Kinahan. "Programmable fluidic networks on centrifugal microfluidic discs." Analytica Chimica Acta 1288 (2024): 342159.
41. Cholkar, Abhijit, Suman Chatterjee, Feljin Jose, Robert O’Connor, Éanna McCarthy, Nick Weston, David Kinahan, and Dermot Brabazon. "Parametric investigation of ultrashort pulsed laser surface texturing on aluminium alloy 7075 for hydrophobicity enhancement." The International Journal of Advanced Manufacturing Technology (2024): 1-18.
40. Cholkar, Abhijit, Suman Chatterjee, Chloe Richards, Éanna McCarthy, Gopinath Perumal, Fiona Regan, David Kinahan, and Dermot Brabazon. "Biofouling and Corrosion Protection of Aluminum Alloys Through Ultrafast Laser Surface Texturing for Marine Applications." Advanced Materials Interfaces (2023): 2300835.
2023
39. Cholkar, Abhijit, Suman Chatterjee, David Kinahan, and Dermot Brabazon. "Ultrafast Laser Fabrication of Microchannels on Aluminium Alloy Substrate." Solid State Phenomena 353 (2023): 37-45.
38. Cholkar, Abhijit, Ronan McCann, Gopinath Perumal, Suman Chatterjee, Mark Swayne, David Kinahan, and Dermot Brabazon. "Advances in laser-based surface texturing for developing antifouling surfaces: a comprehensive review." Applied Surface Science Advances 18 (2023): 100513.
37. Carthy, Éadaoin, Brian Hughes, Eimear Higgins, Phil Early, Cian Merne, Darren Walsh, Anne Parle-McDermott, and David J. Kinahan. "Automated solid phase DNA extraction on a lab-on-a-disc with two-degrees of freedom instrumentation." Analytica Chimica Acta 1280 (2023): 341859.
36. Early, Philip L., Niamh A. Kilcawley, Niamh A. McArdle, Marine Renou, Sinéad M. Kearney, Rohit Mishra, Nikolay Dimov, Macdara T. Glynn, Jens Ducrée, and David J. Kinahan. "Digital process control of multi-step assays on centrifugal platforms using high-low-high rotational-pulse triggered valving." Plos one 18, no. 9 (2023): e0291165.
35. Chekotu, Josiah Cherian, Sujith Kumar, Giulia Degli-Alessandrini, Muhammad Zeeshan Mughal, Russell Goodall, David Kinahan, and Dermot Brabazon. "Formation of β-Ti phase during L-PBF processing of martensitic NiTi." Materials Today Communications 36 (2023): 106668.
34. Chekotu, Josiah Cherian, Giulia Degli-Alessandrini, Muhammad Zeeshan Mughal, Suman Chatterjee, Russell Goodall, David Kinahan, and Dermot Brabazon. "Control of mechanical and shape memory characteristics in martensitic NiTi by setting L-PBF parameters and build orientation." Journal of Materials Research and Technology 25 (2023): 6407-6431.
33. Mishra, Rohit, Lourdes AN Julius, Jack Condon, Patricija Pavelskopfa, Philip L. Early, Matthew Dorrian, Katarina Mrvova, Grace Henihan, Faith Mangwanya, Tanya Dreo, Jens Ducrée, Cor Schoen and David J Kinahan. "Plant pathogen detection on a lab-on-a-disc using solid-phase extraction and isothermal nucleic acid amplification enabled by digital pulse-actuated dissolvable film valves." Analytica Chimica Acta 1258 (2023): 341070.
32. Kilcawley, Niamh A., Toni C. Voebel, Philip L. Early, Niamh A. McArdle, Marine Renou, Jeanne Rio, Godefroi Saint-Martin, Macdara T Glynn, Daniel Zontar, Christoph Brecher, Jens Ducrée and David J Kinahan. "Dissolvable Film-Controlled Buoyancy Pumping and Aliquoting on a Lab-On-A-Disc." Processes 11, no. 1 (2023): 128.
2022
31. Chekotu, Josiah Cherian, David Kinahan, Russell Goodall, and Dermot Brabazon. "Influence of structural porosity and martensite evolution on mechanical characteristics of nitinol via in-silico finite element approach." Materials 15, no. 15 (2022): 5365.
30. Chekotu, Josiah Cherian, Russell Goodall, David Kinahan, and Dermot Brabazon. "Control of Ni-Ti phase structure, solid-state transformation temperatures and enthalpies via control of L-PBF process parameters." Materials & Design 218 (2022): 110715.
29. Regan, Brian, David Kinahan, Philip Daly, Richard O'Kennedy, and David Collins. "Design and fabrication of a low-cost wireless camera imaging system for centrifugal microfluidics." HardwareX 11 (2022): e00259.
28. Mishra, Rohit, Rizwan Alam, Darren McAuley, Tirinder Bharaj, Danielle Chung, David J. Kinahan, Charles Nwankire, Karen S. Anderson, and Jens Ducrée. "Solvent selective membrane routing and microfluidic architecture towards centrifugal automation of customisable bead based immunoassays." Sensors and Actuators B: Chemical 356 (2022): 131305.
2021
27. Zaresharif, Mahshid, Florent Ravelet, David J. Kinahan, and Yan Delaure. "Cavitation control using passive flow control techniques." Physics of Fluids 33, no. 12 (2021).
26. Uddin, Rokon, David Kinahan, Jens Ducrée, and Anja Boisen. "Lab-on-a-disk extraction of PBMC and metered plasma from whole blood: An advanced event-triggered valving strategy." Biomicrofluidics 15, no. 6 (2021).
25. Kinahan, David J., Robert Burger, Daryl Lawlor, Philip L. Early, Abhishek Vembadi, Niamh A. McArdle, Niamh A. Kilcawley, Macdara T. Glynn, and Jens Ducrée. "Centrifugally automated Solid-Phase Extraction of DNA by immiscible liquid valving and chemically powered centripetal pumping of peripherally stored reagents." Biosensors and Bioelectronics: X 9 (2021): 100085.
24. Henderson, Brian D., David J. Kinahan, Jeanne Rio, Rohit Mishra, Damien King, Sarai M. Torres-Delgado, Dario Mager, Jan G. Korvink, and Jens Ducrée. "Siphon-controlled automation on a lab-on-a-disc using event-triggered dissolvable film valves." Biosensors 11, no. 3 (2021): 73.
2020
23. Miyazaki, Celina M., Eadaoin Carthy, and David J. Kinahan. "Biosensing on the centrifugal microfluidic lab-on-a-disc platform." Processes 8, no. 11 (2020): 1360.
2019
22. Burger, Robert, David J. Kinahan, Hélène Cayron, Nuno Reis, João Fonseca, and Jens Ducrée. "Siphon-induced droplet break-off for enhanced mixing on a centrifugal platform." Inventions 5, no. 1 (2019): 1.
2018
21. Miyazaki, Celina M., David J. Kinahan, Rohit Mishra, Faith Mangwanya, Niamh Kilcawley, Marystela Ferreira, and Jens Ducrée. "Label-free, spatially multiplexed SPR detection of immunoassays on a highly integrated centrifugal Lab-on-a-Disc platform." Biosensors and Bioelectronics 119 (2018): 86-93.
20. Delgado, Sarai M. Torres, David J. Kinahan, Lourdes Albina Nirupa Julius, Adam Mallette, David Sáenz Ardila, Rohit Mishra, Celina M. Miyazaki, Jan G. Korvink, Jens Ducrée, and Dario Mager. "Wirelessly powered and remotely controlled valve-array for highly multiplexed analytical assay automation on a centrifugal microfluidic platform." Biosensors and Bioelectronics 109 (2018): 214-223.
2017
19. Glynn, Macdara T., David J. Kinahan, Niamh A. McArdle, Jane L. Kendlin, Triona M. O’Connell, and Jens Ducrée. "A portable optical reader and wall projector towards enumeration of bio-conjugated beads or cells." Plos one 12, no. 12 (2017): e0189923.
18. Miyazaki, Celina M., Rohit Mishra, David J. Kinahan, Marystela Ferreira, and Jens Ducrée. "Polyethylene imine/graphene oxide layer-by-layer surface functionalization for significantly improved limit of detection and binding kinetics of immunoassays on acrylate surfaces." Colloids and Surfaces B: Biointerfaces 158 (2017): 167-174.
17. Brennan, Des, Helena Coughlan, Eoin Clancy, Nikolay Dimov, Thomas Barry, David Kinahan, Jens Ducrée, Terry J. Smith, and Paul Galvin. "Development of an on-disc isothermal in vitro amplification and detection of bacterial RNA." Sensors and Actuators B: Chemical 239 (2017): 235-242.
2016
16. Kinahan, David J., Faith Mangwanya, Robert Garvey, Danielle WY Chung, Artur Lipinski, Lourdes AN Julius, Damien King, Mehdi Mohammadi, Rohit Mishra, May Al-Ofi, Celina Miyazaki, and Jens Ducrée "Automation of silica bead-based nucleic acid extraction on a centrifugal lab-on-a-disc platform." In Journal of Physics: Conference Series, vol. 757, no. 1, p. 012013. IOP Publishing, 2016.
15. Kinahan, David J., Marine Renou, Dirk Kurzbuch, Niamh A. Kilcawley, Éanna Bailey, Macdara T. Glynn, Colette McDonagh, and Jens Ducrée. "Baking powder actuated centrifugo-pneumatic valving for automation of multi-step bioassays." Micromachines 7, no. 10 (2016): 175.
14. Kinahan, David J., Sinead M. Kearney, Niamh A. Kilcawley, Philip L. Early, Macdara T. Glynn, and Jens Ducree. "Density-gradient mediated band extraction of leukocytes from whole blood using centrifugo-pneumatic siphon valving on centrifugal microfluidic discs." PloS one 11, no. 5 (2016): e0155545.
13. Smith, Suzanne, Dario Mager, Alexandra Perebikovsky, Ehsan Shamloo, David Kinahan, Rohit Mishra, Saraí M. Torres Delgado, Horatio Kido, Satadel Saha, Jens Ducrée, Marc Madou, Kevin Land and Jan Korvink "CD-based microfluidics for primary care in extreme point-of-care settings." Micromachines 7, no. 2 (2016): 22.
12. Delgado, Saraí M. Torres, David J. Kinahan, Fralett Suárez Sandoval, Lourdes Albina Nirupa Julius, Niamh A. Kilcawley, Jens Ducrée, and Dario Mager. "Fully automated chemiluminescence detection using an electrified-Lab-on-a-Disc (eLoaD) platform." Lab on a Chip 16, no. 20 (2016): 4002-4011.
11. Kinahan, David J., Philip L. Early, Abhishek Vembadi, Eoghan MacNamara, Niamh A. Kilcawley, Thomas Glennon, Dermot Diamond, Dermot Brabazon, and Jens Ducrée. "Xurography actuated valving for centrifugal flow control." Lab on a Chip 16, no. 18 (2016): 3454-3459.
2015
10. Glynn, Macdara, Charles Nwankire, Kate Lemass, David J. Kinahan, and Jens Ducrée. "Cluster size distribution of cancer cells in blood using stopped-flow centrifugation along scale-matched gaps of a radially inclined rail." Microsystems & Nanoengineering 1, no. 1 (2015): 1-9.
9. Kinahan, David J., Sinéad M. Kearney, Olivier P. Faneuil, Macdara T. Glynn, Nikolay Dimov, and Jens Ducrée. "Paper imbibition for timing of multi-step liquid handling protocols on event-triggered centrifugal microfluidic lab-on-a-disc platforms." RSC advances 5, no. 3 (2015): 1818-1826.
8. Kinahan, David J., Sinéad M. Kearney, Macdara T. Glynn, and Jens Ducrée. "Spira mirabilis enhanced whole blood processing in a lab-on-a-disk." Sensors and Actuators A: Physical 215 (2014): 71-76.
2014
7. Glynn, Macdara, Daniel Kirby, Danielle Chung, David J. Kinahan, Gregor Kijanka, and Jens Ducrée. "Centrifugo-magnetophoretic purification of CD4+ cells from whole blood toward future HIV/AIDS point-of-care applications." Journal of laboratory automation 19, no. 3 (2014): 285-296.
6. Glynn, Macdara T., David J. Kinahan, and Jens Ducrée. "Rapid, low-cost and instrument-free CD4+ cell counting for HIV diagnostics in resource-poor settings." Lab on a Chip 14, no. 15 (2014): 2844-2851.
5. Kinahan, David J., Sinéad M. Kearney, Nikolay Dimov, Macdara T. Glynn, and Jens Ducrée. "Event-triggered logical flow control for comprehensive process integration of multi-step assays on centrifugal microfluidic platforms." Lab on a Chip 14, no. 13 (2014): 2249-2258.
2013
4. Glynn, Macdara T., David J. Kinahan, and Jens Ducrée. "CD4 counting technologies for HIV therapy monitoring in resource-poor settings–state-of-the-art and emerging microtechnologies." Lab on a Chip 13, no. 14 (2013): 2731-2748.
2012 and Earlier
3. Burger, Robert, Daniel Kirby, Macdara Glynn, Charles Nwankire, Mary O'Sullivan, Jonathan Siegrist, David Kinahan, Gerson Aguirre, Gregor Kijanka, Robert A Gorkin III, and Jens Ducrée, "Centrifugal microfluidics for cell analysis." Current opinion in chemical biology 16, no. 3-4 (2012): 409-414.
2. Kinahan, David J., Tara M. Dalton, and Mark R. Davies. "Measurement of substrate thermal resistance using DNA denaturation temperature." International journal of thermal sciences 49, no. 2 (2010): 333-339.
1. Kinahan, David J., Tara M. Dalton, and Mark RD Davies. "Effect of substrate thermal resistance on space-domain microchannel fluorescent melting curve analysis." Biomedical microdevices 11, no. 4 (2009): 747-754.